Stem Cells Therapy

Cellular Therapy: Cellular therapy refers to the use of live cells to replace or repair a damaged organ system. The first widespread use of this approach occurred more than 50 years ago when hematopoietic stem cells (HSCs) from the bone marrow of a healthy donor (allogeneic) were used to replace the hematopoietic system of a recipient after it was ablated during chemo/radio therapy of leukemia, the recipient’s hematopoietic system being “collateral damage” during the eradication of the unwanted leukemia cells. This approach was later extended to the use of Autologous stem cells in various malignant conditions.

Stem cell treatments: are a type of intervention strategy that introduces new cells into damaged tissue in order to treat disease or injury. Many medical researchers believe that stem cell treatments have the potential to change the face of human disease and alleviate suffering. The ability of stem cells to self-renew and give rise to subsequent generations with variable degrees of differentiation capacities, offers significant potential for generation of tissues that can potentially replace diseased and damaged areas in the body, with minimal risk of rejection and side effects.

Adult Stem Cells: A typical adult stem cell is one which, on division, results in one daughter cell that can further differentiate and replenishes a whole compartment or tissue, while the other remains fully “stem” and self-renewing. This is called asymmetric division, and the stem cell is known as multipotent.
The best-studied example of this type of adult stem cell is the hematopoietic stem cell, which produces a trillion differentiated blood cells per day for the life of the animal. This remarkable property is possible because of a complex interaction between the stem cell and other cells and structures within the bone marrow microenvironment called the niche.
The use of adult stem cells in treatment carries neither ethical nor teratoma complications, but these cells are restricted in their cross-tissue differentiation potential. Although claims of adult stem cell plasticity abound, the number of such transdifferentiation events is too small for a meaningful biological effect.

Hematopoietic Stem Cell Transplantation:

Autologous hematopoetic stem cell transplantation (HSCT) refers to the use of the patient’s own stem cells as a rescue therapy after high-dose myeloablative therapy. In contrast, allogeneic HSCT refers to the use of stem cells from a human leucocyte antigen (HLA)– matched related or unrelated donor.

 

TotipotentSC


Indications:
Non-union Fracture
Bone Necrosis (e.g. AVN.)
Cancer Defects A
Bone Defects & Bone gap